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Example text
Extensive clinical use of radioiodine, principally 123I, 124 I, 125I, and 131I, for diagnostic purposes and for treatment of thyrotoxicosis has provided a wealth of information on the effects of relatively high acute exposures on thyroid gland function. Radioiodine is cytotoxic to the thyroid gland at high radiation doses and produces hypothyroidism when doses to the thyroid gland exceed 25 Gy (2,500 rad). Thyroid gland doses of approximately 300 Gy (30,000 rad) can completely ablate the thyroid gland and result in hypothyroidism.
Thyroid hormone deficiency from any cause at critical times of development may result in severe mental retardation, neurologic abnormalities, growth retardation, or abnormal pubertal development. Congenital hypothyroidism secondary to thyroid ablation has been reported subsequent to maternal exposure to ablative doses of 131I. 7 GBq) of 131I during her sixth week of pregnancy. Growth retardation was also observed in ***DRAFT FOR PUBLIC COMMENT*** IODINE 21 2. RELEVANCE TO PUBLIC HEALTH some children who were exposed to radioiodine in the Marshall Island BRAVO cohort, early after the bomb test.
Cases of thyroid gland disorders began to be ***DRAFT FOR PUBLIC COMMENT*** IODINE 17 2. RELEVANCE TO PUBLIC HEALTH Table 2-2. 0011 NRC 1995 related releases Three Mile Island power plant accident a 1 PBq=27,000 Ci ***DRAFT FOR PUBLIC COMMENT*** IODINE 18 2. RELEVANCE TO PUBLIC HEALTH detected in the exposed population in 1964, 10 years after the BRAVO test, particularly in exposed children; these included cases of apparent growth retardation, myxedema (typical of hypothyroidism), and thyroid gland neoplasms.