By Shlomo Melmed MBChB MACP
The Pituitary, 2d variation is the authoritative source at the functionality, disorder and remedy of the pituitary. that includes over four hundred illustrations and tables, the health care provider will achieve a visible realizing of the fabric within the textual content. most sensible endocrinologists and experts from world wide current basically the main exact and present info by:--Providing twenty-one newly revised in-depth chapters, together with a brand new bankruptcy on Pituitary Surgery--Addressing cutting edge issues comparable to new hormone discoveries and new healing advances--Answering the necessity for a unmarried textual content dedicated to uncomplicated body structure and medical elements of pituitary functionality and diseaseWith well known authorship, The Pituitary, second version is a must have textual content!
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Sample text
The Golgi apparatus is prominent and contains pleomorphic immature secretory granules. Scattered secretory granules are fewer and smaller than in storing cells; the diameters range from 150 to 250 nm. Granule extrusions are common and are found not only at the basal cell surface but also on the lateral cell borders, distant from capillaries and basement membranes; the term “misplaced exocytosis” is used to designate this form of granule extrusion. Ultrastructural immunocytology localizes PRL in secretory granules of both cell types; cloudy positivity can also be found in the Golgi region of sparsely granulated forms.
Some also contain immunoreactivity for glial fibrillary acidic protein (GFAP). They have a characteristic morphology, with long, branched cytoplasmic processes embracing granulated adenohypophysial cells (Fig. 26). Because of confusion with the follicular cells described above, some authors have suggested that these cells be called “stellate cells” [289]. They are believed to have a supportive role similar to that played by the S-100-positive sustentacular cells of the adrenal medulla and carotid body.
They vary in electron density and may be 150–700 nm in diameter, most measuring 150–400 nm. While secretory granules may be found lined up along the cell membrane, exocytosis is not described in this cell type. Immunoelectron microscopy identifies the various POMC-derived peptides in the secretory granules of corticotrophs; however, there is no evidence that the morphologic differences of granule populations reflect their content [38]. Corticotrophs are the first cell type to differentiate in the fetal pituitary [220,221]; however, they are found in significantly decreased numbers in anencephaly [276]; it has been suggested that after autonomous differentiation, they are dependent on hypothalamic factors for normal growth and development.