By D R R Williams; et al
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As with cyclosporine, in some – but not all – of the studies, subjects treated with azathioprine had more insulin-free ‘remissions’, lower insulin requirement, and higher glucagon stimulated C-peptide levels. One exception was a study in children aged 2–20. Azathioprine may result in severe leukopenia (but this can be avoided with careful monitoring and dose titration) and there is an unquantified concern about oncogenic potential. As a consequence of fears about potential toxicity, there were no further studies of azathioprine in type 1 diabetes.
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Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, Hara M et al. (2000) Genetic variation in the gene encoding calapin-10 is associated with diabetes mellitus. Nat. Genet. 26: 163–75. 14. Evans JC, Frayling TM, Cassell PG, Saker PJ, Hitman GA, Walker M et al. (2001) Association of the calpain-10 gene with type 2 diabetes mellitus in the United Kingdom. Am. J. Hum. Gen. 69: 544–52. 15. Alshuler D, Hirschorn JN, Klannemark M, Lindgren CM, Vohl MC, Nemesh J et al. (2000) The common PPAR gamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes.