By E.S. Tai, P.J. Gillies, I. Elmadfa
Nutrigenomics seeks to appreciate the range of the individual’s reaction to meals and the underlying mechanisms wherein meals exert their health-promoting actions. With a deeper molecular figuring out of meals, we might a few day manage to layout diets that actually maximize an individual’s power for health and wellbeing and well being. Many Asian societies are at the moment experiencing a transition in diet-related morbidity and mortality. The id and provision of an optimum nutrition suitable to the entire humans dwelling in Asia is a rare problem as there exists an incredible range in nutrition, nutritional consumption styles, neighborhood tradition, and dietary wishes. This quantity explores the function of ethnic range, nutritional styles and genetic model in choosing person nutrient requisites in the course of the life-cycle. Conceptualized as an introductory booklet offering a normal evaluate in addition to particular examples of the functions of thoughts and techniques, this ebook can help scientists, scientific, meals and different health and wellbeing pros to benefit extra in regards to the box of nutrigenomics.
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Additional resources for Nutrigenomics Opportunities in Asia: 1st ILSI International Conference on Nutrigenomics, Singapore, December 2005 (Forum of Nutrition)
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J Obstet Gynaecol Can 2005;27:13–19. Kim YI: 5,10-Methylenetetrahydrofolate reductase polymorphisms and pharmacogenetics: a new role of single nucleotide polymorphisms in the folate metabolic pathway in human health and disease. Nutr Rev 2005;63:398–407. Yang K, Edelmann W, Fan K, Lau K, Leung D, Newmark H, Kucherlapati R, Lipkin M: Dietary modulation of carcinoma development in a mouse model for human familial adenomatous polyposis. Cancer Res 1998;58:5713–5717. Yang WC, Mathew J, Velcich A, Edelmann W, Kucherlapati R, Lipkin M, Yang K, Augenlicht LH: Targeted inactivation of the p21WAF1/cip1 gene enhances Apc-initiated tumor formation and the tumor-promoting activity of a Western-style high-risk diet by altering cell maturation in the intestinal mucosa.
There are different pathways to producing butyrate and it is feasible that not all butyrate-producing bacteria have yet been identified. As we think strategically about developing foods that may be protective against disease, we may need to become more innovative with delivery mechanisms, in order to deliver bioactives to targeted sites of the intestine where their release will maximize the physiological response. Two examples are (1) microencapsulation [41] that can protect the bioactive until a trigger releases its payload at the desired site and (2) butyrate starch ester that resists some upper intestinal digestion and reaches the colon where the butyrate is released where it may help to promote apoptosis and so potentially minimize the risk of developing colorectal cancer [42].
MOP-77741) and the Advanced Foods and Materials Network (M&E-B-4). A. El-Sohemy holds a Canada Research Chair in Nutrigenomics. References 1 2 3 4 5 6 7 8 9 10 Muller M, Kersten S: Nutrigenomics: goals and strategies. Nat Rev 2003;4:315–322. Ordovas JM, Corella D: Nutritional genomics. Annu Rev Genomics Hum Genet 2004;5:71–118. 42 million single nucleotide polymorphisms. Nature 2001;409:928–933. Thorisson GA, Stein LD: The SNP Consortium website: past, present and future. Nucleic Acids Res 2003;31:124–127.