The constitution, functionality and reactions of nucleic acids are principal to molecular biology and are an important for the certainty of complicated organic techniques concerned. Revised and up-to-date Nucleic Acids in Chemistry and Biology third Edition discusses intimately, either the chemistry and biology of nucleic acids and brings RNA into parity with DNA.
Written by means of top specialists, with wide instructing event, this re-creation offers a few up to date and accelerated insurance of nucleic acid chemistry, reactions and interactions with proteins and medicine. a quick historical past of the invention of nucleic acids is via a molecularly dependent advent to the constitution and organic roles of DNA and RNA.
Key chapters are dedicated to the chemical synthesis of nucleosides and nucleotides, oligonucleotides and their analogues and to analytical recommendations utilized to nucleic acids. The textual content is supported via an in depth record of references, making it a definitive reference resource. This authoritative ebook provides subject matters in an built-in demeanour and readable sort. it truly is perfect for graduate and undergraduates scholars of chemistry and biochemistry, in addition to new researchers to the sphere.
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Extra info for Nucleic Acids in Chemistry and Biology (3rd Edition)
Sample text
9). 1) that results from such sideways base displacement. 7 Tautomeric equilibria for deoxycytidine showing hydrogen-bond acceptor a and donor d sites as used in nucleic acid base pairing. 8 Watson–Crick base pairing for CиG (left) and TиA (centre). 9 ‘Wobble’ pairings for UиG (left), UиI (centre) and AиI (right) DNA and RNA Structure 19 Base pairings of these and other non-Watson–Crick patterns is significant in three structural situations. First, the compact structures of RNAs maximise both base pairing and base stacking wherever possible.
2. H. S. Cohen, A century of DNA. MIT Press, Cambridge, MA, 1977. 3. T. M. MacLeod and M. McCarty, Studies on the chemical nature of the substance inducing transformation of pneumococcal types. J. Exp. , 1944, 79, 137–158. 4. F. Miescher, Die histochemischen und physiologischen arbeiten. Vogel, Leipzig, 1897. 5. G. Buchanan and Lord Todd. Adv. Carbohydr. , 2000, 55, 1–13. 6. H. M. R. Todd, Mononucleotides derived from deoxyadenosine and deoxyguanosine. J. Chem. , 1955, 808–815. 7. E. Chargaff, Chemical specificity of nucleic acids and mechanism of their enzymatic degradation.
11). 3 Spectroscopic Properties of Nucleosides and Nucleotides Neither the pentose nor the phosphate components of nucleotides show any significant UV absorption above 230 nm. 2). The light absorptions of isolated nucleoside bases given above are measured in solution in high dilution. They undergo marked changes when they are in close proximity to neighbouring bases, as usually shown in ordered secondary structures of oligo- and poly-nucleotides. In such ordered structures, the bases can stack face-to-face and thus share – electron interactions that profoundly affect the transition dipoles of the bases.