By Anthony H. Barnett, Jenny Grice
Content material:
Chapter 1 Epidemiology and Pathogenesis of sort 2 Diabetes (pages 1–6): Anthony H. Barnett and Jenny Grice
Chapter 2 evaluate of present Diabetes administration (pages 7–16): Anthony H. Barnett and Jenny Grice
Chapter three The Incretin approach (pages 17–19): Anthony H. Barnett and Jenny Grice
Chapter four The Incretin Mimetics (pages 20–32): Anthony H. Barnett and Jenny Grice
Chapter five Dipeptidyl Peptidase?4 Inhibitors (pages 33–45): Anthony H. Barnett and Jenny Grice
Chapter 6 Sodium?Glucose Cotransporter?2 Inhibitors (pages 46–50): Anthony H. Barnett and Jenny Grice
Chapter 7 Pipeline Diabetes cures (pages 51–55): Anthony H. Barnett and Jenny Grice
Chapter eight Bariatric surgical procedure for the remedy of variety 2 Diabetes (pages 56–59): Anthony H. Barnett and Jenny Grice
Chapter nine association of Diabetes Care (pages 60–63): Anthony H. Barnett and Jenny Grice
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Summary of Product Characteristics (UK). Available at: http://emc. uk/medicine/21986/SPC/#INDICATIONS Zinman B, Hoogwerf BJ, Garcia SD, et al. (2007) The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes: a randomized trial. Ann Intern Med; 146:477–485. ; LEAD-4 Study Investigators (2009) Efficacy and safety of the human GLP-1 analog liraglutide in combination with metformin and TZD in patients with type 2 diabetes mellitus (LEAD-4 Met+TZD). Diabetes Care; 32:1224–1230.
Reproduced from Nauck et al . (2007) with permission from Wiley-Blackwell. , 2007). 6% (Rosenstock and Fitchet, 2008). , 2007a). , 2007). , 2007a). 3). , 2007). , 2008). , 2007). , 2007). The improvements in HbA1c with vildagliptin occurred in association with a lower total daily insulin dose and no episodes of significant hypoglycaemia compared with six episodes in those treated with insulin plus placebo. , 2007b). 4% for pioglitazone 30 mg/day monotherapy. 7% in the low dose dual therapy group (vildagliptin 50 mg plus pioglitazone 15 mg daily).
Diabetologia; 50:1148–1155. Galvus SmPC (2009) Novartis Pharmaceuticals UK Ltd. Galvus 50 mg tablets. Summary of Product Characteristics (UK), August 2009. medicines. uk/medicine/20734/SPC/Galvus+50+mg+Tablets Garber AJ, Schweizer A, Baron MA, et al. (2007) Vildagliptin in combination with pioglitazone improves glycaemic control in patients with type 2 diabetes failing thiazolidinedione monotherapy: a randomized, placebo-controlled study. Diabetes Obes Metab; 9:166–174. Garber AJ, Foley JE, Banerji MA, et al.