By Adolf E. Schindler Prof. Dr. med. (auth.)
This monograph represents the 1st entire assessment of hormones in human amniotic fluid and contains info released as much as and together with 1980. lately, extra huge use of amniocentesis for prenatal analysis and evaluate of fetal lung maturation has proven that amniotic fluid hormone measurements can reduction within the analysis of fetal and placental abnormalities. the cloth is gifted in major sections facing steroid and protein hormones. The tools of identity and quantitation are delineated, and the findings are mentioned relating to the medical stipulations. additionally, specific recognition has been directed in the direction of updated evaluate of the assets, metabolism and move of human amniotic fluid hormones. The overview is meant to serve the desires of clinicians, simple scientists and scholars, delivering targeted details on human amniotic fluid hormones so that it will enhance sufferer care and point out chances for additional investigations. Ttibingen, January 1982 A.E. Schindler Contents advent A. 1 beginning of Human Amniotic Fluid . 2 B. C. beginning and law of Steroids in Human Amniotic Fluid . five D. equipment of Isolation and identity of Steroids in Human Amniotic Fluid 6 I. C , C , and C Steroids . 6 30 29 28 II. C Steroids 6 27 1. ldl cholesterol 6 2. Cholestanol . 6 three. ,::l7 -Cholestenol and ,::l8 -Cholestenol. 6 four. 7-Dehydrocholesterol and Desmosterol . 6 ,::l5_C Steroids. III. 7 21 1. Pregnenolone 7 2. 16cx-H ydroxypregnenolone. 7 three. 17cx-Hydroxypregnenolone.
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Extra info for Hormones in Human Amniotic Fluid
Sample text
Lg/liter was present. 0. Half of the cases tested within 72 h of delivery had low amniotic fluid cortisol levels, but some showed subsequent evidence of RDS [157]. A wide scatter of the cortisol and LIS ratio results are obvious from the data by Sivakumaran et al. [147], which correlate with the data grouped according to weeks of gestation as shown in Table 16. Table 16. 001). At the level of more than lOOng/ml cortisol, lung maturity can be expected in 96%. This is comparable to data by Fencl and Tulchinsky [143] and another study [166].
Lg/liter [66]. Lg/liter (mean ± SD) [66]. Lg/liter for the sulfate. Lg/iiter was found with no correlation to gestational age [71]. Lg/liter, respectively [66]. Lg/iiter [66]. By radioimmunoassay, no major changes in concentration during the last trimester were found (268). This was also the case for aldosterone [71]. Lg/liter mea'S~ring the 18-oxoglucuronide [71]. Lg/liter [71a]. 8 ng/ml). Sex differences were not found [70a]. Detailed data for II-deoxycortisol are shown in Fig. 6 [182]. 'o! s 0 0 :E CJ U ~ 0 CJ '" -0 I := ~ 66 0 13 0 0 68 [iiJ \ 14 6 :&0 ~ tP • 0 0 0 0 I 'h 15 16 17 Weeks of gestotion 0 6 ~ ~ 18 ...
Whether or not this is connected to the failure of initiation of labor needs to be explored. The relationship of the conjugated and nonconjugated moieties has not been studied systematically. Lg/liter has been reported in the glucuronide fraction at term [72]. Lg/liter. Lg/liter [73]. b) Complicated Pregnancies In pregnancies complicated by diabetes, hydramnios, anencephaly or severe Rh isoimmunization, the amniotic fluid concentration of pregnanediol did not differ from normal pregnancies [73, 184, 188].