By David Gardner, Dolores Shoback
The popular one-stop consultant to the total box of medical endocrinology and its medical underpinnings – now in complete color
270+ full-color pictures and illustrations!
A Doody's center name for 2011!
4 celebrity DOODY'S REVIEW!
"This is a superb evaluation of the elemental body structure and scientific features of endocrinology for trainees. the dimensions of the e-book and the well-written textual content, supported by means of visible aids, make this a handy booklet to learn and enhance a starting starting place in endocrinology."--Doody's overview Service
Greenspan’s simple & medical Endocrinology, 9e offers a succinct, modern evaluation of the underlying molecular biology of the endocrine procedure and the newest views at the analysis and remedy of particular ailments and problems. that includes an more desirable layout that comes with hundreds of thousands of full-color illustrations and medical images, Greenspan’s is a real must-have in the course of conventional or built-in classes in endocrinology, endocrinology rotation, or for examination prep in inner medication and endocrinology.
Greenspan’s presents clinically appropriate assurance of metabolic bone affliction, pancreatic hormones and diabetes mellitus, hypoglycemia, weight problems, geriatric endocrinology, and lots of different ailments and problems. aiding this crucial fabric is a convenient appendix of standard hormone reference ranges.
Features
- Concise, balanced assurance of either clinical and medical ideas
- the easiest resource for present ideas in endocrine pathophysiology to assist medical selection making
- vital new methods to the scientific administration of endocrine problems, together with healing options
- the main sensible, present insights into diagnostic trying out
- More than 270 full-color illustrations and scientific photographs
Read Online or Download Greenspan's Basic and Clinical Endocrinology, Ninth Edition PDF
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Additional resources for Greenspan's Basic and Clinical Endocrinology, Ninth Edition
Example text
Subunit, a region required for interaction with activated G protein-coupled receptors. Once ADP-ribosylared by pertussis toxin, these G pro reins are no longer able to interact with activated receptors and are thus stuck in an inactive (GDP-bound) conformation. Inhibition of receptor-mediated activation of G, and G0 accounts for many of rhe clinical manifestations of pertussis infection. Genetic mutations in G protein a.. subunits are seen in a num ber of human diseases. , can produce a variety of phenotypes depending on rhe sire of expres sion of the mutant protein.
Three, four, and five nucleosides (ie, n = 3, 4, or 5) are preferred for binding of the VDR, TR, or RAR, respectively. of hormone action must be established either by contextual DNA sequence lying outside the recognition element or by other, non receptor DNA-protein interactions positioned in close proximity to the element. Interestingly, the GR, as well as some other N Rs (eg, ER), are capable of binding to DNA sequence lacking the classic HRE. Originally described in the mouse proliferin gene promoter, these composite elements associate with heterologous CHAPTER I complexes containing G R, as well as with components of the AP- 1 transcription factor complex (ie, c-Jun and c-Fos) .
Thus, in addition to their ability to provide the scaffolding for transcription complex assembly, they also possess the enzymatic capacity to fine rune the transcriptional activity of the complex. In addition to their effects on tran scription, coactivators have been suggested ro be involved in transcript elongation, RNA splicing, and mRNA transport. Recent studies have shown that a significant portion of ER DNA-binding sires in MCF7 lines (breast cancer cell line) are topographically linked to, or in some cases directly overlap with, rhose for the forkl1ead box transcription factor A 1 (FOX A 1 ) .