By Ricardo V. Lloyd MD, PhD (auth.)
Endocrine Pathology integrates classical diagnostic anatomic pathology with contemporary advancements in immunochemistry and molecular biology in its method of endocrine problems. The ebook discusses not just a variety of illnesses usually encountered in daily medical perform but in addition these unusual stipulations elucidated via such leading edge suggestions as ultrastructural immunochemistry and in situ hybridization.
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A) Gross appearance of a follicular adenoma with a distinct microscopic capsule. Each line on the scale represents 1 millimeter (mm). (B) A simple adenoma consisting of follicles with enlarged nuclei and abundant colloid stores. (C) A cellular follicular adenoma with decreased colloid stores. This pattern may be confused with a follicular carcinoma but lacks vascular and capsular invasion. 47 A B c 3. 13. Hiirthle cell adenoma. The neoplastic cells have large granular eosinophilic cytoplasm. There was no evidence of vascular or capsular invasion in this tumor.
The original attachment of the gland to the buccal cavity via a narrow stalk comprising the thyroglossal duct is lost by rupture and resorption and a pit in the tongue, the foramen caecum, is the only remnant. Later in life the distal end of the duct terminates in the pyramidal lobe. Recurrence of the thyroglossal duct may persist at any point along its course, giving rise to ectopic thyroid tissue, cysts, or sinuses (49). The ultimobranchial fourth pharyngeal pouches give rise to the calcitonin-producing Ccells that migrated from the neural crest to this location.
The cut surface of the thyroid is firm, sticky, and glistens due to colloid. The blood supply comes from the superior and inferior thyroid arteries. The lymphatics drain to the deep cervical lymph nodes and to peritracheal and retrostemallymph nodes. The thyroid is composed of follicles that are filled with colloid. The follicular epithelium secretes colloid. The height of the epithelium in the euthyroid state is cuboidal and the follicles rest on a basement membrane. The height of the epithelium varies with physiological and pathological states.