By Guofeng You, Marilyn E. Morris, Binghe Wang
This new version overviews drug transporters and provides the foundations of drug delivery and linked thoughts, that includes new chapters on multidrug and toxin extrusion proteins, placental transport, in silico methods in drug discovery, and regulatory information for drug shipping experiences in drug development.
• Describes drug transporter households, mechanisms, and scientific implications besides experimental equipment for learning and characterizing drug transporters
• Includes new chapters on multidrug and toxin extrusion proteins, placental shipping and in silico techniques in drug discovery
• Has a brand new bankruptcy protecting regulatory counsel for the assessment of drug delivery in drug improvement with worldwide standards used for drug transporters in medical trials
• Arranges fabric to move from primary mechanisms to medical results, making the e-book beneficial for beginner and specialist readers
Read or Download Drug Transporters. Molecular Characterization and Role in Drug Disposition PDF
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Additional resources for Drug Transporters. Molecular Characterization and Role in Drug Disposition
Example text
Apart from the distribution of MPP+ into heart and placental transfer of MPP+ , no significant phenotypic differences have been observed in Oct3 –/– mice. 7. , the effect of natural human genetic variation in drug transporter genes on drug disposition and drug response). , amino acid substitutions, or insertions or deletions in the coding region), followed in some cases by functional studies of the variant proteins in heterologous expression systems. 1. OCT1 Several functionally significant polymorphisms in OCT1 have been described.
J Biol Chem 276(36):33741–33746. 58. Cetinkaya I, Ciarimboli G, Yalcinkaya G, Mehrens T, Velic A, Hirsch JR, Gorboulev V, Koepsell H, Schlatter E. 2003. Regulation of human organic cation transporter hOCT2 by 32 59. 60. 61. 62. 63. 64. 65. 66. 67. 68. 69. 70. 71. ORGANIC CATION TRANSPORTERS PKA, PI3K, and calmodulin-dependent kinases. Am J Physiol Renal Physiol 284(2):F293– F302. Pelis RM, Suhre WM, Wright SH. 2006. Functional influence of N-glycosylation in OCT2mediated tetraethylammonium transport.
D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. D. Substrate 33 18 18,20 20,32 18,20 20,32 20,32 18 18 18 18,20 37 20,30 20,30 34 18,20 20 20,32 20,69 20,32 20 20 20,69 20,32 18,20 18,20 Refs. ” (not determined) for that isoform. a Includes compounds that have been tested as either substrates or inhibitors of any OCT isoform.