By Gerald Litwack (Eds.)

Steroids is a thematic quantity from the vintage educational Press sequence, Vitamins and Hormones . Gerald Litwack, the hot editor of this prestigious serial, brings jointly major individuals to the learn of steroids. those structurally and functionally advanced molecules are of curiosity to a wide cross-section of endocrinologist, mobile biologists, and biochemists. stories contain stories of constitution, functionality, and law of steroid construction and motion. hence, Vitamins and Hormones maintains to submit state-of-the-art experiences of curiosity to endocrinologists and biochemists. Others will more and more flip to this carrying on with sequence for accomplished stories through major researchers during this and comparable disciplines.

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6 of the phosphate backbone) and so may be recognizing the local conformation of the DNA. If this were changed to a serine (as in the GRdbd) it would almost certainly perturb the orientation of the recognition helix. Finally, the alanine in the ER P-box (that is equivalent to the valine in the GRdbd) makes no contact with the DNA. If it were charged to a valine, it would almost certainly perturb the polar nature of the interface. Two of the base contacts are nearly equivalent in the GR/GRE and ER/ERE complexes.

FREEDMAN response element. Gln at this position could not reach the base. Arg50 interacts with a DNA phosphate and is buttressed in this interaction by a hydrogen bond with Asp6, a residue that is absolutely conserved in the corresponding position throughout the superfamily. Substitution of the Arg with Gln would allow one but not both of these interactions to be made. Arg57 forms a phosphate backbone contact, and a Gln side chain here would not be sufficiently long to duplicate this interaction.

Tsai, S. , and O'Malley, B. W. (1992). Members of the steroid hormone receptor superfamily interact with TFIIB (S300-11). Biol. Chem. 267,17617-17623. , and Green, S. (1990). Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators. Nature (London) 347, 645-650. , Miller, W. , Warrell, R. , Frankel, S. , Murty, V. V. V. , and Evans, R. M. (1991). Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RARa with a novel putative transcription factor, PML.

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