By A.P. Simopoulos, J.A. Milner, B. Koletzko
Knowledge of the effect of our genetic version to nutritional reaction (nutrigenetics) and the way meals could have an effect on gene expression (nutrigenomics) is prompting a revolution within the box of food. Nutrigenetics/Nutrigenomics offer robust techniques to solve the complicated relationships between dietary molecules, genetic versions and the organic approach. This book comprises chosen papers from the '3rd Congress of the overseas Society of Nutrigenetics/Nutrigenomics' held in Bethesda, Md., in October 2009. The contributions handle frontiers in nutrigenetics, nutrigenomics, epigenetics, transcriptomics in addition to non-coding RNAs and posttranslational gene laws in a number of ailments and stipulations. as well as clinical experiences, the demanding situations and possibilities dealing with governments, academia and the are integrated. every body attracted to the way forward for customized medication and nutrients or agriculture, in addition to researchers in academia, executive and will locate this ebook of the maximum curiosity for his or her paintings.
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Diabetes 1998;47:487–489. 31 Jang Y, Kim OY, Lee JH, et al: Genetic variation at the perilipin locus is associated with changes in serum free fatty acids and abdominal fat following mild weight loss. Int J Obes 2006;30:1601–1608 Nutrigenetics and Personalized Nutritional Therapy for Obesity 31 32 Corella D, Qi L, Sorlí JV, et al: Obese subjects carrying the 11482G>A polymorphism at the perilipin locus are resistant to weight loss after dietary energy restriction. J Clin Endocrinol Metab 2005;90:5121– 5126.
16 Puri · Manku A small 6-month randomized double-blind placebo-controlled trial of pure ethylEPA in stage III Huntington’s disease showed that the fatty acid intervention was associated with improvement on the orofacial component of the Unified Huntington’s Disease Rating Scale, while all the patients on placebo deteriorated on this scale [25]. Following subvoxel sinc-interpolation-based registration of follow-up 3D MRI brain scans with baseline scans [26], subtraction images showed that while the placebo was associated with progressive cerebral atrophy, the ethyl-EPA was associated with a reverse process [25].
Br J Nutr 2009;101(suppl 2):S73–S85. 10 Ishkanian AS, Malloff CA, Watson SK, et al: A tiling resolution DNA microarray with complete coverage of the human genome. Nat Genet 2004;36:299–303. 11 Couzin J: Human genome: HapMap launched with pledges of $100 million. Science 2002;298:941–942. 12 Shelling AN, Ferguson LR: Genetic variation in human disease and a new role for copy number variants. Mutat Res 2007;622:33–41. 13 Ioannidis JP, Thomas G, Daly MJ: Validating, augmenting and refining genome-wide association signals.