By Robert Brunet

This ebook introduces a unique framework for the optimum layout of sustainable chemical tactics. Our strategy combines technique simulation, multi-objective optimization instruments (MOO), monetary research, lifestyles cycle review (LCA) and choice aid platforms (DSS). The constructed method might be used to unravel very complicated difficulties. For that it'll be essential to enhance new algorithms and decomposition thoughts to divide the unique challenge in additional conceivable sub-problems, to procure the optimum layout of the method.

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This constraint imposes an upper limit on the value of the secondary objective. Model (MA) is then solved for different values of the auxiliary parameter in order to generate the entire Pareto set of solutions. Thus, if MA is solved for all possible values of and the resulting solutions are unique, then these solutions represent the entire Pareto set of solutions of the original multi-objective problem. If the solutions to MA are not unique for some values of , then the Pareto points must be picked by direct comparison.

Jagschies G. Where is Biopharmaceutical Manufacturing Heading. BioPharm International 2008;10:72-88. Hwang F. Batch pharmaceutical process design via simulation. Pharmaceutical Engineering 1997;17:28-43. Petrides DP, Koulouris A, Lagonikos PT. The role of process simulation in pharmaceutical process development and product commercialization. Pharmaceutical Engineering 2002;22:56-65. Petrides DP, Koulouris A, Siletti C. Throughput analysis and debottlenecking of biomanufacturing facilities, a job for process simulators.

2012a,b). The methodology is tested using a well-known pharmaceutical process: the production of the antibiotic Penicillin V. 2 PROBLEM STATEMENT The optimization problem of the single-product pharmaceutical process can be formally stated as follows. Given are the annual production, the final product price, cost parameters, time horizon, thermodynamic properties, performance models of the units and LCA data. The goal is to determine the optimal process design, including equipment sizes, structural alternatives and operating conditions that simultaneously maximizes the economic performance, quantified via the Net Present Value (NPV), and minimize the environmental impact (EI), measure according to LCA principles.

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