By Gould R.F. (ed.)
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X Genetics . . . . . . . . . . . . . . . . . Distribution of Kv7 Channels . . . . . . . . . . . . . Biophysical Properties of Kv7 Channels . . . . . . . . . . Pharmacological Agents to Modulate Kv7 Channels . . . . . . Effects of Kv7 Channels on Electrical Activity of Sensory Neurons . . Evidence for a Role of Kv7 Channels in Pain: Pre-Clinical in Vivo Studies Experience in Man . . . . . . . . . . . .
41. 42. 43. 44. Recent Advances in Ion Channel Screening Technologies 25 45. Gill S, Gill R, Lee SS, Hesketh JC, Fedida D, Rezazadeh S, Stankovich L, Liang D (2003) Assay Drug Dev Technol 1:709–717 46. Aurora Biomed (2007) Ion channel reader series. htm. Last accessed 2 May 2008 47. Sorota S, Zhang XS, Margulis M, Tucker K, Priestley T (2005) Assay Drug Dev Technol 3:47–57 48. Chaudhary K, O’Neal JM, Mo ZL, Fermini B, Gallavan RH, Bahinski A (2006) Assay Drug Dev Technol 4:73–82 49. Asmild M, Oswald N, Krzywkowski KN et al.
2 inhibition is effective against all types of neuropathic pain. 2 knockout animals, one additional question that arises is whether deficits are observed under more detailed analysis. Mangoni et al. 1 knockout and specifically bradycardia and slowing of atrioventricular conduction. 1. 1 channel is the dominant gene family member in the heart. 1 (–/–) mice, Mangoni et al. (2006) state that “T-type (Cav3) channel inhibition would have no deleterious consequences on cardiac physiology” and speculate about the potential utility of Cav3 blockers in cardiovascular applications as well as those for epilepsy and pain.