By Joseph I. Boullata, Vincent T. Armenti

This instruction manual offers a necessary compilation of present details on drug-nutrient interactions that may allow healthiness care prone to raised deal with their sufferers. It bargains evidence-based scientific concepts for lots of interactions, and serves as an important device for clinicians to take advantage of in realizing, deciding on, distinguishing, predicting, optimizing, coping with and combating major hostile drug-nutrient interactions on the way to optimize sufferer care.

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Extra resources for Handbook of Drug-nutrient Interactions

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Harkness R, Bratman S. ). The Natural Pharmacist: Drug–Herb-Vitamin Interactions Bible. Prima Communications, Rocklin, CA, 2001. 28. Pronsky ZM, Crowe JP, et al. ). ). Food Medication Interactions, 2001. 29. Tatro DS. ). Drug Interaction Facts: Herbal Supplements and Food. Facts and Comparisons, St. Louis, MO, 2002. 30. Couris RR, Tataronis GR, Dallal GE, et al. Assessment of healthcare professionals’ knowledge about warfarin-vitamin K drug-nutrient interactions. J Am Coll Nutr 2000;19:439–445.

Lipid peroxidation induced by ceftizoxime was reduced by ascorbic acid (123). Ascorbic acid has been used in the treatment of nucleoside reverse transcriptase inhibitor-related mitochondrial toxicity (88). Consider how much of the variability in adverse effects attributed to a medication may have a direct or indirect nutritional explanation. In vitro findings cannot necessarily be extrapolated to in vivo or clinical situations. Ascorbyl palmitate reversibly inhibits CYP3A4 in vitro, exhibiting strong competitive inhibition of nifedipine oxidation, but this is not supported by in vivo data during a singledose study (124).

12. Winick M. ). Nutrition and Drugs. Wiley, New York, NY, 1983. 13. Roe DA, Campbell TC. Drugs and Nutrients: the Interactive Effects. Marcel Dekker, New York, NY, 1984. 14. Roe DA. ). AVI Publishing, Westport, CT, 1985. 15. Schwartz J, Williams R, Savage J. Connections: Nutrition, Contraception, Women, Eating. Sun Rose Associates, 1985. 16. Morgan BLG. Food and Drug Interaction Guide. Simon & Shuster, New York, NY, 1986. 17. Roe DA. Diet and Drug Interactions. Wiley, New York, NY, 1988. 18. Weibert RT, Norcross WA.

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