By Joao Carlos Setubal, Sergio Verjovski-Almeida

This booklet constitutes the refereed complaints of the Brazilian Symposium on Bioinformatics, BSB 2005, held in Sao Leopoldo, Brazil in July 2005.

The 15 revised complete papers and 10 revised prolonged abstracts offered including three invited papers have been conscientiously reviewed and chosen from fifty five submissions. The papers tackle a extensive diversity of present themes in computational biology and bioinformatics.

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Additional info for Advances in Bioinformatics and Computational Biology: Brazilian Symposium on Bioinformatics, BSB 2005, Sao Leopoldo, Brazil, July 27-29, 2005, Proceedings

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If some unrestricted flux ri belonging to the jth cycle is negative, it can be made positive by reversing the sign of the corresponding entries in the ith column of the G and K matrices, namely G∗i Perturbing Thermodynamically Unfeasible Metabolic Networks 35 and K∗i respectively. If after this transformation, any of the rows of the K matrix still has the same sign, then the flux vector is thermodynamically unfeasible, and we detect the presence of a cycle. By satisfying this condition we can eliminate the non-linear constraint in equation (5), transforming the non-linear problem into a linear one.

Trabalhador S˜ ao-Carlense, 400 - Centro - Cx. br Abstract. Many cellular functions are carried out in compartments of the cell. The cellular localization of a protein is thus related to its function identification. This paper investigates the use of two Machine Learning techniques, Support Vector Machines (SVMs) and Decision Trees (DTs), in the protein cellular localization prediction problem. Since the given task has multiple classes and SVMs are originally designed for the solution of two class problems, several strategies for multiclass SVMs extension were investigated, including one proposed by the authors.

1973) Network thermodynamics: Dynamic Modelling of Biophysical Systems, Quart. Rev. Biophys. 6, 1-134. 7. Papin, J. , Price, N. , Wiback, S. , Fell, D. A. and Palsson, B. O. (2003) Metabolic Pathways in the Post-genome Era, Trends in Biochemical Sciences 28, 250-258. 8. Price, N. , Beard, D. A. and Palsson, B. O. (2002) Extreme Pathways and Kirchhoff’s Second Law, Biophys. J. 83 2879-2882. 9. , Beard, D. and Liang, S. (2003) Stoichiometric Network Theory for Nonequilibrium Biochemical Systems, Eur.

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