By V. T. Marchesi (auth.), Barry D. Kahan, Ralph A. Reisfeld (eds.)
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Additional info for The Cell Surface: Immunological and Chemical Approaches
Sample text
MARCHESI: Concerning the time lag - if you add exogenous ganglioside to the cell, is there a correlation with the amount of gangliOSide you can add? CUATRECASAS: No, we cannot shorten the lag period beyond a certain point. We can lengthen it, but we cannot shorten it. EDELMAN: Do you have any idea how big that hydrophobic central core might be? Is it as you depict it, which would suggest 30 angstroms. CUATRECASAS: extended chain. It is at a maximum around 30 angstroms, if it were an EDELMAN: Is it true of other glycolipids that they seem to be anchored as well, not just this specific set, but the general family of glycolipids.
I stress that these are ideas and not conclusions. The molecules which I am discussing as representative of these two classes are immunoglobulin and H-2 alloantigens, the major histocompatibility antigens of mice. Both of these molecules are presumed to be recognition units on the surface of lymphocytes. If one enzymatically radio -iodinates intact mouse splenocytes, both molecules on the surface of cells are labelled. Incubation of such splenocytes for approximately six hours in vitro, during which time there is no evidence of cell death, releases about 50 per cent of the iodinated immunoglobulin surface molecules into the medium.
Many of the sugar sequences that occur in glycoJipids and glycoproteins are also found in the freeoligosaccharides of human milk (Ginsburg, Advances in Enzymology, Vol. 36, ed. A. Meister John Wiley & Sons, New York, 1972, p. 131). We*have been isolating and characterizing these oligosaccharides for use in immunologic studies 0 n the carbohydrates of cell surface. They are much easier to isolate t han their counterparts in membranes and can be obtained in relatively I a r g e ,~ This work was carried out in collaboration with Dr.