By Werner Ebeling
This can be a ebook concerning the actual approaches in reacting complicated molecules, really biomolecules. some time past decade scientists from varied fields resembling drugs, biology, chemistry and physics have amassed a big quantity of information concerning the constitution, dynamics and functioning of biomolecules. nice development has been accomplished in exploring the constitution of advanced molecules. even though, there's nonetheless a scarcity of knowing of the dynamics and functioning of organic macromolecules. specifically this refers to enzymes, that are the elemental molecular machines operating in residing structures. This e-book contributes to the exploration of the actual mechanisms of those procedures, concentrating on serious facets corresponding to the function of nonlinear excitations and of stochastic results. an intensive variety of unique effects has been bought within the previous few years by means of the authors, and those effects are provided including a entire survey of the state-of-the-art within the box.
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Erfus, E. L. Peticolas (1972): "Conformationally dependent low-frequency motion of proteins by laser RAMAN-spectroscopy", PNAS USA 69, 1467. L. Charles Brooks III, Martin Karplus and B. Montgomery Petitt (1988): "Proteins. Theoretical Perspective of Dynamics, Structure, and Thermodynamics", Series Advances in Chemical Physics Vol. 71, John Wiley and Sons, New York. S. I. E. Shnol (1987): "The Concept of 'proteinmachine' and its consequences" (in Russian), Molek. Biol. 20, 1356-1368. S. M. Chernavskaya (1999): "Protein-machine.
028. 30) This is a two-parameter potential similar as the LJ-potential which however is more realistic with respect to the description of the repulsion between the molecules. The parameter b determines the stiffness of the potential. The diameter a is not well defined for this potential. g. 31) The exponential potential is not singular at r = 0 and is in close correspondence to the results of quantum-mechanical calculations for the repulsive forces. The repulsion is heavily based on the Pauli principle which prevents any overlap of the electron clouds of the molecules.
Ebeling, A. Engel, R. Feistel: (1990): "Physik der Evolutionsprozesse", AkademieVerlag, Berlin, Russ. TransL: URSS, Moscow (2001). W. Ebeling, M. Jenssen (1992): "Trapping and fusion of solitons in a nonuniform Toda lattice", Physica D 32, 183-193; Physica A 188, 350. W. Ebeling,W. & M. Jenssen (1991) "Soliton-Assisted Activation Processes", Ber. Bunsenges. Phys. Chem. 95, 356-362. W. Ebeling, Yu. Romanovsky, Yu. Khurgin, A. Netrebko, N. Netrebko, E. Shidlovskaya (1994): "Complex regimes in the simple models of molecular dynamics of enzymes", Proc.