By Sally Radovick, Margaret H. MacGillivray
An updated and concise consultant to the medical administration of pediatric endocrine issues. The textual content covers the commonest and hard stipulations noticeable via working towards endocrinologists and first care physicians, together with progress, hypothalamic, pituitary, adrenal, thyroid, calcium and bone, and reproductive problems, in addition to metabolic syndromes. every one bankruptcy includes an introductory dialogue of the matter, a assessment of the medical positive aspects that symbolize it, the standards had to determine a prognosis, and a entire treatment part delineating the hazards and advantages of the simplest healing strategies to be had. worthy tables summarize the serious components in etiology, medical presentation, analysis, and healing dosages.
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Additional info for Pediatric Endocrinology: A Practical Clinical Guide (Contemporary Endocrinology)
Example text
The higher incidence for type II DM indicates that the use of GH in predisposed individuals might accelerate the onset of diabetes (238). LEUKEMIA Concern was raised about the development of de novo leukemia after a cluster of leukemia in patients under GH therapy was reported in Japan in 1988 (239). However, recent data from Japan obtained from more than 32,000 GH-recipients reported the development of leukemia in 14 cases for an incidence of 3/100,000 patient years, not higher than in the general population (240).
In addition, the number and height of surges of GH secretion must be assessed. Six to ten surges, with at least four of them with a GH concentration over 10 ng/L, must be present in a normal subject. The test is difficult to perform, expensive, and unspecific. No normative data for comparison purposes are available. This method uncovers GH deficiency in children who have had a normal GH response to provocative tests after cranial irradiation. 05% of the total daily circulating GH. Although the measurement of GH in urine is more reliable because of the use of ultrasensitive enzyme-linked immunosorbent assays and immunoradiometric assays (206), the interpretation of the results is difficult due to large inter- and intra-individual variation and the effect of renal function.
J Lab Clin Med 1957; 49:825. 48. Rinderknecht E, Humbel RE. The amino acid sequence of human insulin-like growth factor I and its structural homology with proinsulin. J Biol Chem 1978;253(8):2769–2776. 49. Daughaday WH, Rotwein, IP. Insulin-like growth factors I and II. Peptide, messenger ribonucleic acid and gene structures, serum, and tissue concentrations. Endo Rev 1989;10(1):68–91. 50. Gluckman PD, Barrett-Johnson JJ, Butler JH, et al. Studies of insulin-like growth factor I and II by specific radioligand assays in umbilical cord blood.