By NADIR R. FARID

- This sequence is listed in index Medicus

- The flip round time for this sequence is quickly, making the study as actual as a journal

 

Show description

Read Online or Download Molecular Basis of Thyroid Cancer PDF

Best endocrinology & metabolism books

Obesity and Diabetes (Practical Diabetes)

Kind 2 diabetes, linked to weight problems, is this present day the most typical kind of diabetes. В it's also linked to a few different cardiovascular possibility elements which represent the metabolic syndrome. В powerful administration of diabesity is essential to the relief of morbidity and untimely morbidity as a result of heart problems.

Essential Biochemistry, Endocrinology and Nutrition

Biochemistry is the learn of the chemistry of residing organisms, of the ways that meals is used to serve the entire many wants of the physique. Biochemistry is heavily attached with nutrients, the learn of the categories and quantities of assorted fabrics required within the nutrition. Biochemistry can be inextricably int~rtwined with endo­ crinology, the learn of hormones, for many of the hormones exert their activities via changing the behaviour of chemical reactions in the physique.

Additional info for Molecular Basis of Thyroid Cancer

Sample text

Hürthle cells have been studied by enzyme histochemistry and have been shown to contain a high level of oxidative enzymes (145,146). Somatic mutations and sequence variants of mitochondrial DNA (mtDNA) have been identified in oncocytic thyroid carcinomas (147,148). Similar changes have been found in the nontumorous thyroid tissue of patients with oncocytic neoplasms (148), suggesting that certain polymorphisms predispose to this cytologic alteration. Hürthle cells are sometimes considered to be a cause of concern in needle biopsies (57).

Most studies have indicated that morbidity and mortality for patients with non-metastatic encapsulated follicular carcinoma is very low and correlates better with 32 2. Thyroid cancer pathology patient age than with any other parameter. Some have suggested that capsular invasion alone does not alter the incidence of distant metastases or cancer-related death (33). Since the incidence of follicular carcinoma is low (43), most investigators still advocate total thyroidectomy and radioactive iodine therapy (34,49,50).

Individual cells, follicles or groups of follicles may show Hürthle cell features in irradiated thyroids, in ageing thyroids, in nodular goitre and in thyroiditis as well as in long-standing autoimmune hyperthyroidism (142). One can see these cells in chronic lymphocytic thyroiditis, in Graves’ disease and in nodular goitre, where one can often find an entire nodule composed of oncocytes. Hürthle cell adenoma and carcinoma For many years it was felt that all Hürthle cell neoplasms of the thyroid (Figure 15) should be considered malignant since it was felt that the histology could not predict clinical behaviour.

Download PDF sample

Rated 4.46 of 5 – based on 17 votes