By Henryk Kozlowski;David R Brown;Gianni Valensin
Read or Download Metallochemistry of neurodegeneration : biological, chemical, and genetic aspects PDF
Best chemical books
Monosaccharide Sugars. Chemical Synthesis by Chain Elongation, Degradation, and Epimerization
''This e-book offers in-depth, accomplished entry to an unlimited physique of literature on artificial reactions regarding carbohydrates. the quantity is a mine of data both worthy for looking a realistic strategy for creating a sugar-based beginning fabric and for comprehending the effect of a managed chiral atmosphere at the consequence of an artificial transformation.
W Tungsten: Metal, Chemical Reactions with Metals Zinc to Lawrencium
The current quantity keeps the outline of the chemical reactions of eiemental tungsten begun with "Tungsten" Suppl. Vol. A 7. It covers the reactions with the metal components from zinc to actinoids. The remedy comprises section diagrams, bulk reactions, and floor approaches which back are of remarkable value in so much platforms.
Modelling of chemical wear : relevance to practice
Modeling of Chemical put on is a one-stop source for college students, researchers and execs looking quickly and potent tribological reviews of environmentally pleasant and effort effective items. This publication considers optimizing additive combos by way of right method, bridging the distance among conception and perform.
- Chemical Mutagens: Principles and Methods for Their Detection Volume 8
- Cellular ceramics : structure, manufacturing, properties and applications
- Metallic Coatings for Corrosion Control
- Chemical and functional properties of food saccharides
Additional info for Metallochemistry of neurodegeneration : biological, chemical, and genetic aspects
Example text
Contrary to what occurs in Menkes’ disease, in Wilson’s disease the blood concentration of Cu becomes unusually high when the liver, damaged by Cu accumulation, releases the metal directly into the bloodstream. Thus, Cu ions are carried throughout the body, damaging other organs. Wilson’s patients with neurological symptoms show elevated Cu levels in cerebrospinal fluid (CSF). One of the most significant advances in recent years has been the linking of a series of neurodegenerative diseases to alterations in the metabolism of copper.
Apel. , 1991, 16, 172. C. B. Denman, Curr. Top. , 1984, 24, 153. J. Henriksson and H. Tja¨lve, Toxicol. , 2000, 55, 392. M. , Exp. , 1998, 149, 277. CHAPTER 3 Metal Ion-Induced Redox Reactions, Oxidative Stress and Possible Impact on Neurodegeneration Oxygen is one of the critical molecules for life processes. However, its metabolites, the reactive oxygen species (ROS), are very toxic to cells. Postmortem examination of the brain tissues of the patients with Alzheimer disease (AD) or Parkinson disease (PD) clearly shows the high level of damage caused by ROSinducing reactions.
100 mtDNA is located close to the site of mitochondrial ROS production, which seems to be mainly complex I involving FeS clusters. 102 This effect may result from the fact that rotenone is a selective complex I inhibitor causing the increase of the oxidation stress in mitochondrion, but the systemic administration of rotenone does not lead to serious mitochondrial dysfunction. A reduced form of glutathione (GSH), a very effective reducing agent, plays an important role during the oxidation process.