By Minghan Wang

This ebook presents a accomplished evaluation of the advance of metabolic syndrome, the underlying mechanisms and healing ideas for drug improvement. The authors research the context of underlying molecular pathways and built-in body structure, then increasing the dialogue to illnesses linked to metabolic syndrome. the advance of drug treatments for those ailments and problems is widely coated. The publication deals a complete and in-depth view of power metabolism, metabolic tissues and pathways, molecular mechanism-based drug discovery and scientific implications.

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MAGNAN, G. MITHIEUX, and F. ANDREELLI. 2008. Intestinal gluconeogenesis is a key factor for early metabolic changes after gastric bypass but not after gastric lap-band in mice. Cell Metab 8:201–211. Chapter 2 Central Glucose Sensing and Control of Food Intake and Energy Homeostasis LOURDES MOUNIEN1,2 1 2 AND BERNARD THORENS1,2 Department of Physiology, University of Lausanne, Lausanne, Switzerland Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland INTRODUCTION Glucose plays an essential role in energy homeostasis by regulating the secretion of various hormones and the activation of neuronal circuits controlling feeding and energy expenditure (1, 2).

R. , U. D. C. G. B. M. M. IGNAR, S. I. MUIR. 2003. The orphan G protein-coupled receptor GPR40 is activated by medium and long chain fatty acids. J Biol Chem 278:11303–11311. 59. , P. STENEBERG, and H. EDLUND. 2008. Gpr40 is expressed in enteroendocrine cells and mediates free fatty acid stimulation of incretin secretion. Diabetes 57:2280–2287. 60. , K. TSUMAYA, T. AWAJI, S. KATSUMA, T. ADACHI, M. YAMADA, Y. SUGIMOTO, S. MIYAZAKI, and G. TSUJIMOTO. 2005. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120.

B. R. M. BUCHAN. 1997. Expression of the calcium-sensing receptor on human antral gastrin cells in culture. J Clin Invest 99:2328–2333. 28. H. I. GROSSMAN. 1978. Stimulation of gastrin release in dogs by individual amino acids. Proc Soc Exp Biol Med 157:440–441. 22 Chapter 1 Gut as an Endocrine Organ 29. , T. RADECKI, P. THOR, and A. DEMBINSKI. 1973. Release of cholecystokinin by amino acids. Proc Soc Exp Biol Med 143:305–309. 30. , and V. MAXWELL. 1978. Intravenous infusion of amino acids stimulates gastric acid secretion in man.

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