By U.S. Von Euler (Eds.)

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Soc. Exptl. Biol. Med. 100, 138-139. Schally, Α. , and Guillemin, R. (1960). 1st Intern. Congr Endocrinol. Copenhagen* Abstr. Communs. p. 63. Schally, Α. , Andersen, R. , Lipscomb, H. , Long, J. , and Guillemin, R. (I960). Nature 188, 1192-1194. Schally, Α. , Lipscomb, H. , Long, J. , Dear, W. , and Guillemin, R. (1962)· Endocrinology 70, 478-480. , and Long, Μ. E. (1950). Endocrinology 47, 454-457. Scow, A. , and Greer, M. A. (1955). Endocrinology 56, 590-596. Shealy, C. , and Peele, T. L. (1957).

In the rat, for ex­ ample, whose posterior pituitary may contain 1000 m U antidiuretic activity, about 3-15 μ ϋ vasopressin/100 gm body weight are secreted per minute (Dicker, 1954). 2 μ ϋ / m l or 5-19 μ ϋ in the total blood volume. The latter figure is of the same order as the minimum (intravenous) antidiuretic dose. 2. NEUROHYPOPHYSEAL HORMONES 41 The ratio of vasopressor-antidiuretic to oxytocic activity in extracts of the International Standard powder is, by definition, one. But this ratio is not, strictly speaking, the same as the ratio of the amounts of pure peptides in the gland.

Beare, Professor of Latin, University of Bristol, who translated Santorini's remarks. 2. NEUROHYPOPHYSEAL HORMONES 27 animals like Necturus (Green and Maxwell, 1959). The morphology of the pituitary gland varies somewhat in different groups of reptiles, birds, and mammals but the differences are superficial (de Beer, 1926; Hanström, 1957; Dodd, 1960). All neurohypophyses contain the terminals of axons which originate in cell groups of the anterior hypothalamus and form the hypophyseal tract. In fishes and amphibians there is essentially only a single group of cells, the nucleus preopticus, situated on each side of the third ventricle.

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