By Takashi Sugimura (auth.), Hideya Endo, Tetsuo Ono, Takashi Sugimura (eds.)

During the decade a substantial physique of information has come into life referring to a category of carcinogenic molecules mainly represented by means of 4-nitroquinoline i-oxide. unique papers in this topic are a number of and largely scattered over many branches of technology; it used to be felt that those papers may be reviewed and the data introduced jointly in a single quantity earlier than it grew to become too unwieldy. This we've got tried to do during this monograph. Our objective has been to incorporate all suitable papers released so far, in order that it could function an epitome of the current prestige of information in this very important topic. we've got been lucky in securing the cooperation of a number of colleagues who've contributed chapters, each one facing one point of the topic. we have now been doubly lucky in that those individuals, like ourselves, have been at one time or one other contributors of the gang belonging to the medical employees of Dr. WARO NAKA­ HARA, Director of the nationwide melanoma heart study Institute, Tokyo, Japan.

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Extra info for Chemistry and Biological Actions of 4-Nitroquinoline 1-Oxide

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One culture out of eight developed a transformed colony. These transformed cells were confirmed as malignant by transplantation into hamster. It should be noted that in some experiments even a single treatment with 4-hydroxyaminoquinoline l-oxide caused the transformation of the cells. 4-Hydroxyaminoquinoline l-oxide is known to lose its inactivating effect for bacteriophage T4 within 10 to 15 minutes in the presence of oxygen in the neutral to alkaline range (IsHIzAwA and ENDo, 1967). Therefore in transformation experiments, the actual duration of the effect of 4-hydroxyaminoquinoline l-oxide might be less than 15 minutes.

1963) IRINO et al. (1963) MORI (1964 a) TANAKA et al. (1963) SEARLE and WOODHOUSE (1963) TANAKA et al. (1963) SHIRASU et al. (1962) ~1962) BABA et al. c. ij. c. m. c. Site and route Table 1 (continued) 16/34 squamous cell carcinoma 61/79 squamous cell carcinoma 40/105 papilloma 14/105 carcinoma 62/63 papilloma 8163 carcinoma 1/63 adenoma 4/16 sarcoma 7/16 lung cancer 4/16 uterine cancer 11/16 leukemia 23/260 connective tissue tumor 28/260 squamous cell carcinoma 21/260 epithelial tumor 2/20 early neoplastic lesion 16/46 adenocarcinoma 154/160 pulmonary tumor 37/160 leukemia 1/31ibrosarcoma Animals with tumors 80 weeks 357 days 22 months over 180 days 137 days 6 months 230 days l year Duration of experiment SEARLE and SPENCER (1966) MORI (1965) HORmetal.

1 ml, 6 times at intervals of 10 days ddN 20 mice 300 days 400 days 400 days 190-200 days 300 days 300 days KAWAZOE et al. (1967) KAWACHI et aI. (1965) KAWACHI et al. (1967) NAKAHARA et al. (1958) KAWAZOE et al. (1967) KAWAZOE et al. j>. P. I'SQ 0 S· 42 H. ENDO In 1961, MaRl and YASUNO succeeded in inducing multiple pulmonary tumors by a single injection of 4-nitroquinoline l-oxide. In this experiment dd mice were found to be more susceptible than C57bl mice. Perhaps more noteworthy was the observation of MaRl (1961) that repeated subcutaneous injections in mice of 4-nitroquinoline l-oxide produced multiple pulmonary tumors, including well-established adenocarcinoma with metastases.

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