By Connie M. Weaver, Robert P. Heaney

This entire overview of the country of our wisdom relating calcium not just demonstrates its significance to human future health, but in addition defines its many complicated roles. The authors summarize the most recent simple medical details at the mobile and metabolic features of calcium, explaining the major suggestions for properly measuring its bioavailability, absorption, and kinetics, and exhibiting that calcium deficiency is an immense challenge whereas calcium extra an extraordinary one. additionally they study the complicated law of calcium absorption, distribution, and excretion, in addition to the a number of interactions of diet/lifestyle, and actual task in calcium homeostasis. Their dialogue of the explicit roles of calcium in various scientific disorders-osteoporosis, oral well-being, weight problems, reproductive issues, and the metabolic syndrome-provides new insights and increases new questions. The complicated alterations in calcium and phosphate law that happen in renal illness and the aptitude function of calcium in high blood pressure and vascular ailment also are addressed.

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The activity of the NCX is apparently reduced in myocardial ischemia, leading to intracellular Ca2+ overload which can result in arrhythmia, myocardial stunning, and necrosis (131). On the other hand, congestive heart failure and myocardial hypertrophy are associated with increased NCX activity and decreased inotropic state. 4. OVERVIEW OF WHOLE-BODY CALCIUM HOMEOSTASIS Under normal conditions, the maintenance of Ca2+ balance in the body is the result of the interplay among the intestines, kidney, and bone; the placenta is also involved in the maintenance of this balance during pregnancy.

Taylor CW, Marshall IC. Calcium and inositol 1,4,5-trisphosphate receptors: a complex relationship. Trends Biochem Sci 1992;17:403–407. 82. Gordienko DV, Bolton TB. Cross-talk between ryanodine receptors and IP3 receptors as a factor shaping spontaneous Ca2+-release events in rabbit portal vein myocytes. J Physiol 2002;542:743–762. 83. Taylor CW, Traynor D. Calcium and inositol trisphosphate receptors. J Membr Biol 1995;145:109–118. 84. Gu X, Spitzer NC. Distinct aspects of neuronal differentiation encoded by frequency of spontaneous Ca2+ transients.

Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells. Evidence that an intracellular calcium pool and not an inositol phosphate regulate calcium fluxes at the plasma membrane. J Biol Chem 1989;264:12,266– 12,271. 45. Putney JW, Jr. Capacitative calcium entry revisited. Cell Calcium 1990;11:611–624. 46. Putney JW, Jr, Bird GSJ. The inositol phosphate-calcium signaling system in no-excitable cells. Endocr Rev 1993;14:610–631. 47. , Garcia-Sancho, J. and Alvarez J.

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