By Gideon Polya

This completely listed publication summarizes a wealth of data at the biochemical goals of plant protective compounds, and is an a useful reference for all biomedical pros.

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Additional info for Biochemical Targets of Plant Bioactive Compounds: A Pharmacological Reference Guide to Sites of Action and Biological Effects

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Simple coumarins (Phe I pyran-2-one) include coumarin and a variety of antibacterial derivatives including ammoresinol (7-hydroxy-3-geranylgeranylcoumarin), daphnetin (7,8dihydroxycoumarin), esculetin (6,7-dihydroxycoumarin), esculin (esculetin 6-0-glucoside), herniarin (7-methoxycoumarin) and umbelliferone (7-hydroxycoumarin). Fraxetin and 4-methyldaphnetin (6,7-dimethoxycoumarin) are antioxidant ROS scavengers and 5-LOX inhibitors. Esculetin, 7-hydroxy-4-methylcoumarin and umbelliferone are xanthine oxidase inhibitors.

The non-specific biocidal properties of phenols give rise to dermatitic properties. Noted plant phenol dermatitics include anacardic acids (2-hydroxy-6-(long chain alky1)-benzoic acids), catechol (1,2-dihydroxybenzene), ginkgol (3-(pentadec-8-enyl)phenol), Grevillea robusta (Proteaceae) grevillol (1,3-dihydroxy-5-tridecylbenzene), salicylic acid (2-hydroxybenzoic acid), sesamol (3,4-methylene dioxyphenol), Turricula parryi (poodle dog bush) and the 70xicodendron (Hydrophyllaceae) turricolol E (1,4-dihydroxy-2-(tri-isopreny1)benzene) radicans (poison ivy) (Anacardiaceae) 3-(long chain alkeny1)-catechols.

Furanochromones (furan I Phe I y-pyran-4-one) have a furan ring fused with the benzene moiety of the chromone. Khellin, the related khellol glucoside and visnagin (dehydrokhellin) derive from seeds of Ammi uknaga (Apiaceae),both khellin and visnagin being phototoxic and vasorelaxant CAMPphosphodiesterase inhibitors. Pyranochromones (or-pyran I Phe I y-pyran-4-one) have an or-pyran ring fused with the benzene ring of the chromone and include the Cneorunz species (Cneoraceae) antibacterial and cytotoxic compounds pulverochromenol (having an or-pyran fused with 28 1.

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