By David A. Bender
Amino Acid Metabolism, 3rd Edition covers all features of the biochemistry and dietary biochemistry of the amino acids. beginning with an outline of nitrogen fixation and the incorporation of inorganic nitrogen into amino acids, the e-book then information different significant nitrogenous compounds in micro-organisms, vegetation and animals. Contents contain a dialogue of the catabolism of amino acids and different nitrogenous compounds in animals, and the microbiological reactions concerned about unencumber of nitrogen gasoline again into the ambience. Mammalian (mainly human) protein and amino acid specifications are thought of intimately, and the tools which are used to figure out them.
Chapters contemplate person amino acids, grouped in accordance with their metabolic starting place, and discussing their biosynthesis (in vegetation and micro-organisms for those who are nutritional necessities for human beings), significant metabolic roles (mainly in human metabolism) and catabolism (again quite often in human metabolism). there's additionally dialogue of regulatory mechanisms for these kinds of metabolic pathways, and of metabolic and genetic illnesses affecting the (human) metabolism of amino acids.
Throughout the publication the emphasis is at the dietary value of amino acids, integration and keep an eye on of metabolism and metabolic and different disturbances of relevance to human biochemistry and health.
- Completely revised variation of this entire textual content masking all of the most up-to-date findings in amino acid metabolism research
- Written via an expert within the box
- Covers new advances in structural biology
- Clear illustrations of all constructions and metabolic pathways
- Full checklist of urged extra interpreting for every bankruptcy and bibliography of papers mentioned within the text
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Additional info for Amino Acid Metabolism
There is a nerve-tissue speciﬁc isoenzyme of glutamate dehydrogenase which has a lower Km for glutamate than the liver enzyme and is more sensitive to activation by ADP and leucine, but is insensitive to inhibition by GTP. It is only in tissues that catalyze gluconeogenesis that succinyl CoA synthetase in the citric acid cycle catalyzes substrate-level phosphorylation to yield GTP; in other tissues, the enzyme catalyzes phosphorylation of ADP to ATP. , 2009). 4 Glutamate synthase – the glutamine pathway of ammonium incorporation Directly or indirectly, glutamate and glutamine provide ﬁxed nitrogen for almost all of the nitrogenous compounds in bacteria and plants.
Plants store nitrogen rather than eliminating it, and allantoin and allantoic acid are important nitrogen storage compounds in tropical legumes. 2. , 2006). There is an obvious need to maintain an appropriate balance between the intracellular concentrations of adenine and guanine nucleotides – and also, because of their role in metabolic regulation, to maintain appropriate concentrations of both AMP and GMP as well as adenosine, which has a major role in cell signalling. In order to achieve this, there is continual catabolism of AMP and GMP.
4 Mammalian enzymes that utilize phosphoribosyl pyrophosphate. 2 PRPP amidotransferase The synthesis of phosphoribosylamine from PRPP is the ﬁrst committed step of purine synthesis, and the main regulatory step. It is also the ﬁrst step for synthesis of the pyrimidine ring of thiamin (vitamin B1). , 2007). The activity of human PRPP amidotransferase is exquisitely sensitive to the intracellular concentration of PRPP, having an apparent Km of 140 μmol/l, compared with a normal intracellular concentration of 2–30 μmol/l.